Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 10/20 | 0.67 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.67 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5727947 | 0.95 | AKT2 (0.74) | AKT2PDPK1PDK1NAMPTKMT2A | |
| SCHEMBL5728277 | 0.87 | AKT2 (0.75) | AKT2PDPK1PDK1 | |
| SCHEMBL5728695 | 0.85 | AKT2 (0.91) | AKT2PDPK1PDK1 | |
| SCHEMBL5728697 | 0.85 | AKT2 (0.91) | AKT2PDPK1PDK1 | |
| SCHEMBL5728141 | 0.85 | AKT2 (0.89) | AKT2PDPK1PDK1 | |
| SCHEMBL5728138 | 0.85 | AKT2 (0.89) | AKT2PDPK1PDK1 | |
| SCHEMBL5728256 | 0.82 | AKT2 (0.71) | AKT2PDPK1PDK1 | |
| SCHEMBL5727915 | 0.82 | AKT2 (0.88) | AKT2PDPK1PDK1 | |
| SCHEMBL5727928 | 0.82 | AKT2 (0.88) | AKT2PDPK1PDK1 | |
| SCHEMBL5728656 | 0.80 | AKT2 (1.00) | AKT2PDPK1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680401-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | Schering Aktiengesellschaft (DE) | 2006-07-19 | — | — | EP | claimed |
| WO-2005040116-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-05-06 | — | — | WO | claimed |
| EP-1680401-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | Schering Aktiengesellschaft (DE) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040116-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-05-06 | — | — | WO | disclosed |