Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 18/20 | 0.71 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.59 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5727947 | 0.84 | AKT2 (0.74) | AKT2PDPK1PDK1KDR | |
| SCHEMBL5727779 | 0.83 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL5727776 | 0.83 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL5728448 | 0.82 | AKT2 (0.67) | AKT2PDPK1PDK1 | |
| SCHEMBL5728277 | 0.82 | AKT2 (0.75) | AKT2PDPK1PDK1 | |
| SCHEMBL5728340 | 0.76 | AKT2 (0.85) | AKT2PDPK1PDK1 | |
| SCHEMBL5728337 | 0.76 | AKT2 (0.85) | AKT2PDPK1PDK1 | |
| SCHEMBL5728462 | 0.74 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL5728458 | 0.74 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL5728581 | 0.69 | AKT2 (0.58) | AKT2PDPK1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680401-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | Schering Aktiengesellschaft (DE) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040116-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-05-06 | — | — | WO | disclosed |