Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 14/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476387 | 0.85 | AKT2 (0.81) | AKT2PDPK1PDK1 | |
| SCHEMBL3476390 | 0.85 | AKT2 (0.81) | AKT2PDPK1PDK1 | |
| SCHEMBL3471350 | 0.74 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL3471348 | 0.74 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL5728256 | 0.69 | AKT2 (0.71) | AKT2PDPK1PDK1 | |
| SCHEMBL3477254 | 0.69 | AKT2 (0.68) | AKT2PDPK1PDK1 | |
| SCHEMBL3477256 | 0.69 | AKT2 (0.68) | AKT2PDPK1PDK1 | |
| SCHEMBL3470401 | 0.66 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL5728100 | 0.66 | AKT2 (1.00) | AKT2PDPK1PDK1 | |
| SCHEMBL3470275 | 0.66 | AKT2 (0.79) | AKT2PDPK1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680401-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | Schering Aktiengesellschaft (DE) | 2006-07-19 | — | — | EP | claimed |
| WO-2005040116-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-05-06 | — | — | WO | claimed |
| EP-1680401-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | Schering Aktiengesellschaft (DE) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040116-A2 | INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-05-06 | — | — | WO | disclosed |