SCHEMBL5728985

SCHEMBL5728985

CC(CCO)Cc1ccc(C#N)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.47
LOXL2 Q9Y4K0 2/20 0.44
MAOB P27338 1/20 0.40
IDO1 P14902 2/20 0.39
DPP4 P27487 1/20 0.39
FAP Q12884 1/20 0.39
DPP8 Q6V1X1 1/20 0.39
DPP9 Q86TI2 1/20 0.39
DPP7 Q9UHL4 1/20 0.39
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
MMP12 P39900 1/20 0.38
MMP13 P45452 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CA12 O43570 1/20 0.38
CA2 P00918 1/20 0.38
CA3 P07451 1/20 0.38
CA6 P23280 1/20 0.38
CA9 Q16790 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9902676 0.85 CYP2A6 (0.50) CYP2A6LOXL2MAOBIDO1CYP11B1
SCHEMBL13643101 0.85 CYP2A6 (0.50) CYP2A6LOXL2MAOBIDO1CYP11B1
SCHEMBL19407082 0.84 CYP2A6 (0.53) CYP2A6LOXL2MAOBIDO1HRH3
SCHEMBL29038971 0.81 CYP2A6 (0.50) CYP2A6LOXL2MAOBALDH1A1ACACB
SCHEMBL10441823 0.79 CYP2A6 (0.57) CYP2A6LOXL2MAOBIDO1CYP11B1
SCHEMBL7658469 0.79 TSHR (0.53) CYP2A6LOXL2TSHRHSD17B10CYP19A1
SCHEMBL21396259 0.79 TSHR (0.53) CYP2A6LOXL2DPP4HRH3MMP12
SCHEMBL10091330 0.79 TSHR (0.53) CYP2A6LOXL2DPP4HRH3MMP12
SCHEMBL18930737 0.79 LOXL2 (0.47) CYP2A6LOXL2IDO1DPP4FAP
SCHEMBL28288513 0.78 CYP2A6 (0.50) CYP2A6LOXL2MAOBIDO1CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1720836-A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2006-11-15 EP disclosed
WO-2005082859-A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2005-09-09 WO disclosed