Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2363937 | 0.93 | ALDH1A1 (0.35) | ALDH1A1TSHRLMNACYP2C19 | |
| SCHEMBL9818046 | 0.80 | ALDH1A1 (0.36) | ALDH1A1TSHRLMNACYP2C19HTT | |
| SCHEMBL11652322 | 0.76 | ALDH1A1 (0.33) | ALDH1A1TSHRLMNACYP2C19 | |
| SCHEMBL11649668 | 0.76 | ALDH1A1 (0.33) | ALDH1A1TSHRLMNACYP2C19 | |
| SCHEMBL4045851 | 0.76 | ALDH1A1 (0.33) | ALDH1A1TSHRLMNACYP2C19 | |
| SCHEMBL7403368 | 0.75 | ALDH1A1 (0.34) | ALDH1A1TSHRLMNACYP2C19HTT | |
| SCHEMBL11652789 | 0.72 | CYP2C19 (0.43) | ALDH1A1TSHRLMNACYP2C19HTT | |
| SCHEMBL9298312 | 0.72 | ALDH1A1 (0.32) | ALDH1A1TSHRLMNACYP2C19HTT | |
| SCHEMBL11649367 | 0.69 | TSHR (0.34) | ALDH1A1TSHRLMNACYP2C19HTT | |
| SCHEMBL4042093 | 0.67 | ALDH1A1 (0.30) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003740-A2 | PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGOISTS | Abbott Laboratories (US) | 2000-05-31 | — | — | EP | claimed |
| WO-1999006397-A2 | PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1999-02-11 | — | — | WO | claimed |
| WO-1997046549-A1 | ANTI-NEURODEGENERATIVELY EFFECTIVE XANTHENE DERIVATIVES | NOVARTIS AG (CH) | 1997-12-11 | — | — | WO | claimed |
| US-4786571-A | ELECTROGRAPHY | MINOLTA CAMERA KABUSHIKI KAISHA (JP) | 1988-11-22 | — | — | US | claimed |
| EP-1695964-A1 | Quinoline derivatives for use as intermediates in the synthesis of heterocyclylalcoyl piperidines | NOVEXEL (FR) | 2006-08-30 | — | — | EP | disclosed |
| US-6809111-B2 | ANTIINFLAMMATORY AGENTS; ANALGESICS | PHARMACIA CORPORATION | 2004-10-26 | — | — | US | disclosed |
| US-4786571-A | ELECTROGRAPHY | MINOLTA CAMERA KABUSHIKI KAISHA (JP) | 1988-11-22 | — | — | US | disclosed |
| US-4235904-A | HYPOCHOLESTEROLEMIC, HYPOLIPEMIC, ANTIULCER, ANTIHISTAMINIC AND ANTISEROTONINIC ACTIVITIES | INSTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1980-11-25 | — | — | US | disclosed |
| US-4091222-A | ANTIINFLAMMATORY, ANTIPYRETIC, ANALGESIC, ANTITUSSIVE, CNS EFFECTS, ANAESTHETICS, ANTIARRHYTHMIC, HYPOTENSIVE, ANTICOAGULANTS | MANGHISI ELSO | 1978-05-23 | — | — | US | disclosed |
| US-4061637-A | CNS, CARDIOVASCULAR, ANTIINFLAMMATORY, ADRENOLYTIC, ANTIULCER | ISTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1977-12-06 | — | — | US | disclosed |
| US-3988475-A | ANAESTHETICS, ANTIARRHYTHMIA, HYPOTENSIVES, ADRENERGIC | ISTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1976-10-26 | — | — | US | disclosed |
| US-3970672-A | 2,2 Disubstituted-benzodioxoles | ISTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1976-07-20 | — | — | US | disclosed |