Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 2/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8507926 | 0.88 | MAPT (0.39) | GAAALDH1A1CYP2C19RAB9ASMN1; SMN2 | |
| Carbamic Acid SCHEMBL28658378 | 0.86 | MAPT (0.38) | GAAALDH1A1CYP2C19RAB9ASMN1; SMN2 | |
| SCHEMBL34259 | 0.84 | GAA (0.48) | GAAMAPT | |
| Fumaric Acid SCHEMBL4504232 | 0.83 | ALDH1A1 (0.37) | GAAALDH1A1CYP2C19RAB9ALMNA | |
| Maleic Acid SCHEMBL4504225 | 0.83 | ALDH1A1 (0.37) | GAAALDH1A1CYP2C19RAB9ALMNA | |
| Citric Acid SCHEMBL164689 | 0.82 | ALDH1A1 (0.42) | ALDH1A1CYP2C19SMN1; SMN2LMNACYP1A2 | |
| Cadaverine Tartrate SCHEMBL3996512 | 0.82 | GAA (0.34) | GAARAB9ALMNAMAPTNPC1 | |
| Cadaverine Tartrate SCHEMBL3996515 | 0.82 | GAA (0.34) | GAARAB9ALMNAMAPTNPC1 | |
| Tartaric Acid SCHEMBL30548416 | 0.82 | GAA (0.34) | GAARAB9ALMNAMAPTNPC1 | |
| Trifluoroacetic Acid SCHEMBL5465747 | 0.82 | CES1 (0.39) | GAARAB9AMAPTNPC1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720836-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005082859-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2005-09-09 | — | — | WO | disclosed |