Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.51 |
| ▸ | PDE1A | P54750 | 5/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729942 | 0.90 | PDE5A (0.43) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5729394 | 0.89 | PDE5A (0.49) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5731611 | 0.84 | PDE5A (0.51) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5730383 | 0.83 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5884355 | 0.81 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5730277 | 0.80 | PDE5A (0.49) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5883869 | 0.80 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5884416 | 0.80 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5884403 | 0.80 | PDE5A (0.50) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL5731099 | 0.79 | PDE5A (0.51) | PDE5APDE1APDE1BPDE1CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060293326-A1 | 2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases | BAYER HEALTHCARE AG (DE) | 2006-12-28 | — | — | US | disclosed |
| EP-1399439-B1 | 2-HETEROARYL-IMIDAZOTRIAZINONES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES | BAYER HEALTHCARE AG (DE) | 2006-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293326-A1 | 2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases | REL, AHR, SULT2A1 | PDE5A 3518/4885PDE1A 4223/4885PDE1B 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.