Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 6/20 | 0.34 |
| ▸ | FEN1 | P39748 | 6/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5883635 | 0.85 | PDE5A (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2PDE5A | |
| SCHEMBL5730051 | 0.82 | PDE5A (0.44) | KDM4EPKMHPGDERCC1FEN1 | |
| SCHEMBL5729824 | 0.81 | CNR2 (0.36) | KDM4EPKMHPGDERCC1FEN1 | |
| SCHEMBL5883597 | 0.81 | PDE5A (0.38) | HPGDALDH1A1MEN1KMT2APDE5A | |
| SCHEMBL5730268 | 0.78 | PDE5A (0.51) | KDM4EPKMHPGDERCC1FEN1 | |
| SCHEMBL5730413 | 0.78 | PDE5A (0.49) | KDM4EPKMHPGDERCC1FEN1 | |
| SCHEMBL5729111 | 0.76 | ADORA1 (0.44) | KDM4EPKMHPGDERCC1FEN1 | |
| SCHEMBL5883977 | 0.75 | KHK (0.34) | MEN1KMT2AADORA3PDE5AADORA1 | |
| SCHEMBL5730854 | 0.74 | PDE5A (0.43) | KDM4EPKMHPGDERCC1FEN1 | |
| SCHEMBL5730856 | 0.74 | PDE5A (0.43) | KDM4EPKMHPGDERCC1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060293326-A1 | 2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases | BAYER HEALTHCARE AG (DE) | 2006-12-28 | — | — | US | disclosed |
| EP-1399439-B1 | 2-HETEROARYL-IMIDAZOTRIAZINONES AND THEIR USE IN THE TREATMENT OF INFLAMMATORY OR IMMUNE DISEASES | BAYER HEALTHCARE AG (DE) | 2006-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293326-A1 | 2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases | REL, AHR, SULT2A1 | KDM4E 2863/4885PKM 3696/4885HPGD 887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.