SCHEMBL5730171

SCHEMBL5730171

Cc1oc(-c2ccccc2)nc1CCOc1[c]c(CNC(=O)OC(C)C)ccc1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.62
PPARA Q07869 15/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5729379 0.92 PPARG (0.57) PPARGPPARA
SCHEMBL5730765 0.89 PPARG (0.50) PPARGPPARA
SCHEMBL5729663 0.88 PPARG (0.51) PPARGPPARA
SCHEMBL5350843 0.88 PPARG (0.51) PPARGPPARA
SCHEMBL5729735 0.86 PPARG (0.49) PPARGPPARA
SCHEMBL5351857 0.85 TP53 (0.59) PPARGPPARA
SCHEMBL5352380 0.84 PPARG (0.48) PPARGPPARA
SCHEMBL5363280 0.84 PPARG (0.49) PPARGPPARA
SCHEMBL5352172 0.83 PPARG (0.51) PPARGPPARA
SCHEMBL5729514 0.83 PPARG (0.51) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401434-B1 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) LILLY CO ELI (US) 2006-11-15 EP claimed
EP-1401434-B1 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) LILLY CO ELI (US) 2006-11-15 EP disclosed