Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 7/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322761 | 0.90 | PRKCI (0.52) | PRKCIHTR2CKDM4EMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL1321749 | 0.89 | PRKCI (0.51) | PRKCIHTR2CKDM4EMAPTALDH1A1 | |
| SCHEMBL5731318 | 0.86 | HTR2C (0.60) | PRKCIHTR2CKDM4EMAPTCHRM4 | |
| SCHEMBL5731174 | 0.85 | PRKCI (0.66) | PRKCIKDM4EMAPTMAPK1TSHR | |
| SCHEMBL2614862 | 0.85 | PRKCI (0.54) | PRKCIHTR2CKDM4EMAPTTP53 | |
| SCHEMBL5732255 | 0.81 | PRKCI (0.44) | PRKCIHTR2CKDM4EALDH1A1CYP1A2 | |
| SCHEMBL19805185 | 0.78 | PRKCI (0.48) | PRKCIHTR2CMAPTALDH1A1MAPK1 | |
| SCHEMBL1322086 | 0.77 | PRKCI (0.43) | PRKCIHTR2CKDM4EMAPTALDH1A1 | |
| SCHEMBL5731659 | 0.76 | HTR2C (0.62) | PRKCIHTR2CMAPTTDP1KMT2A | |
| SCHEMBL1322263 | 0.75 | PRKCI (0.50) | PRKCIHTR2CKDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |