Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | PRKCI | P41743 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731659 | 0.90 | HTR2C (0.62) | HTR2CPRKCITOP1TOP2AMAPT | |
| SCHEMBL5730181 | 0.86 | PRKCI (0.54) | HTR2CPRKCIKDM4ECHRM4IKBKB | |
| SCHEMBL5731354 | 0.84 | PRKCI (0.69) | HTR2CPRKCIKDM4EABCB1ABCG2 | |
| SCHEMBL5730721 | 0.84 | PRKCI (0.56) | HTR2CPRKCIKDM4EABCB1ABCG2 | |
| SCHEMBL1322761 | 0.84 | PRKCI (0.52) | HTR2CPRKCIKDM4EABCB1ABCG2 | |
| Hydrochloric Acid SCHEMBL1321749 | 0.83 | PRKCI (0.51) | HTR2CPRKCIKDM4EABCB1ABCG2 | |
| SCHEMBL1321336 | 0.83 | HTR2C (0.55) | HTR2CPRKCIKDM4E | |
| SCHEMBL5732076 | 0.81 | PRKCI (0.58) | HTR2CPRKCIKDM4EABCB1ABCG2 | |
| SCHEMBL1322086 | 0.76 | PRKCI (0.43) | HTR2CPRKCIKDM4EIKBKBMAPT | |
| SCHEMBL5732255 | 0.75 | PRKCI (0.44) | HTR2CPRKCIKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |