Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450328 | 0.77 | KDM4E (0.31) | — | |
| SCHEMBL4486828 | 0.75 | PRMT5 (0.32) | PRMT5 | |
| SCHEMBL29957143 | 0.75 | PRMT5 (0.32) | PRMT5 | |
| SCHEMBL4498158 | 0.66 | PRMT5 (0.39) | PRMT5 | |
| SCHEMBL4313476 | 0.63 | NOTUM (0.45) | — | |
| SCHEMBL29953424 | 0.58 | SSTR4 (0.30) | — | |
| SCHEMBL2723162 | 0.58 | ALDH1A1 (0.45) | — | |
| SCHEMBL17224442 | 0.58 | KMT2A (0.38) | — | |
| SCHEMBL263719 | 0.57 | ALDH1A1 (0.42) | — | |
| SCHEMBL3242496 | 0.57 | CYP1A2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615898-B1 | 2-Aminopyrimidine derivatives and their medical use | NOVARTIS AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| EP-1615898-A1 | 2-AMINOPYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | Novartis AG (CH) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089913-A1 | AMINOPYRIMIDINE DERIVATIVES AND THEIR MEDICAL USE | NOVARTIS AG (CH) | 2004-10-21 | — | — | WO | disclosed |