Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.42 |
| ▸ | HPGD | P15428 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5730265 | 0.85 | MAPT (0.48) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL5730914 | 0.83 | MEN1 (0.39) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL5730449 | 0.83 | MEN1 (0.43) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL5730959 | 0.81 | HPGD (0.40) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL5730893 | 0.81 | HRH3 (0.39) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL1321736 | 0.80 | PRKCI (0.43) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL5731014 | 0.79 | PRKCI (0.42) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL5731595 | 0.75 | MAPT (0.41) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL5731794 | 0.74 | MAPT (0.47) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL5730721 | 0.73 | PRKCI (0.56) | MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |