Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5730265 | 0.87 | MAPT (0.48) | HPGDMEN1KMT2AMAPTPOLB | |
| SCHEMBL5730449 | 0.85 | MEN1 (0.43) | HPGDMEN1KMT2AMAPTPOLB | |
| SCHEMBL5730914 | 0.83 | MEN1 (0.39) | HPGDMEN1KMT2AMAPTPOLB | |
| SCHEMBL5730959 | 0.83 | HPGD (0.40) | HPGDMEN1KMT2AMAPTPOLB | |
| SCHEMBL5730887 | 0.82 | HTR2C (0.42) | HRH3KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL5730731 | 0.81 | MEN1 (0.42) | HPGDMEN1KMT2AMAPTPOLB | |
| SCHEMBL5731595 | 0.77 | MAPT (0.41) | HPGDMEN1KMT2AMAPTPOLB | |
| SCHEMBL5731794 | 0.77 | MAPT (0.47) | HPGDMEN1KMT2AMAPTPOLB | |
| SCHEMBL1321427 | 0.72 | MAPT (0.44) | HPGDMEN1KMT2AMAPTPOLB | |
| SCHEMBL5730721 | 0.71 | PRKCI (0.56) | MEN1KMT2AMAPTKDM4ECHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |