Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | GFER | P55789 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | BRS3 | P32247 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5730153 | 0.86 | GFER (0.62) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL5731591 | 0.85 | KMT2A (0.64) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL5730004 | 0.82 | KMT2A (0.64) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL5732051 | 0.73 | CYP2D6 (0.54) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL5731407 | 0.73 | MAPT (0.66) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL3163430 | 0.72 | MAPT (0.65) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL3180041 | 0.71 | KMT2A (0.63) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL5732498 | 0.70 | MAPT (0.66) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL5730135 | 0.70 | CYP1A2 (0.70) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL5731436 | 0.70 | MAPT (0.66) | KMT2AGFERMAPTSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | Aventis Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014555-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-02-17 | — | — | WO | disclosed |