SCHEMBL5730870

SCHEMBL5730870

CC(N)CNc1ncccn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.50
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
KMT2A Q03164 1/20 0.40
PCSK9 Q8NBP7 3/20 0.40
HRH4 Q9H3N8 3/20 0.38
PRKCI P41743 2/20 0.36
HPGD P15428 1/20 0.36
ESR1 P03372 1/20 0.35
CCNE2 O96020 1/20 0.35
CCNA2 P20248 1/20 0.35
CCNE1 P24864 1/20 0.35
CDK2 P24941 1/20 0.35
CCNA1 P78396 1/20 0.35
FDPS P14324 1/20 0.35
CYP1A2 P05177 1/20 0.35
PRKCB P05771 1/20 0.35
PRKCA P17252 1/20 0.35
PRKCH P24723 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11922543 0.82 ALDH1A1 (0.54) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL17353594 0.78 ALDH1A1 (0.52) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL19936087 0.77 ALDH1A1 (0.48) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL12373452 0.77 ESR1 (0.45) MEN1KMT2AHRH4ESR1CCNE2
SCHEMBL14198659 0.76 CYP2D6 (0.56) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL1831588 0.76 CYP2D6 (0.56) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL25948006 0.74 ALDH1A1 (0.45) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL17700184 0.73 ALDH1A1 (0.54) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL15208762 0.72 GRIN3B (0.45) ALDH1A1MEN1NPC1RAB9AKMT2A
SCHEMBL5575974 0.72 GRIN2D (0.51) ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1613629-A1 SUBSTITUTED 4-AMINO 1,2,4 TRIAZOLO 4,3-A QUINOXALINES Pfizer Products Inc. (US) 2006-01-11 EP disclosed
WO-2004085439-A1 SUBSTITUTED 4-AMINO[1,2,4]TRIAZOLO[4,3-A]QUINOXALINES PFIZER PRODUCTS INC. (US) 2004-10-07 WO disclosed
US-6100268-A MIGRAINES JANSSEN PHARMACEUTICA, N.V. (BE) 2000-08-08 US disclosed
US-5824682-A Vasoconstrictive dihydrobenzopyran derivatives JANSSEN PHARMACEUTICA, N.V. (BE) 1998-10-20 US disclosed
EP-0714396-A1 VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1996-06-05 EP disclosed
WO-1995005383-A1 VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1995-02-23 WO disclosed
WO-1993017017-A1 [(BENZODIOXAN, BENZOFURAN OR BENZOPYRAN)-ALKYLAMINO] ALKYL SUBSTITUTED GUANIDINES AS SELECTIVE VASCOCONSTRICTORS JANSSEN PHARMACEUTICA N.V. (BE) 1993-09-02 WO disclosed