Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3297432 | 0.91 | MEN1 (0.43) | MEN1KMT2AATMADRA2BADRA2A | |
| SCHEMBL3251169 | 0.91 | MEN1 (0.43) | MEN1KMT2AATMADRA2BADRA2A | |
| SCHEMBL3255880 | 0.88 | KDM1A (0.45) | MEN1KMT2AATMKDM1AMAOA | |
| SCHEMBL3248354 | 0.88 | KDM1A (0.45) | MEN1KMT2AATMKDM1AMAOA | |
| SCHEMBL3259028 | 0.85 | ALDH1A1 (0.39) | MEN1KMT2AATMALDH1A1HRH4 | |
| SCHEMBL3256675 | 0.85 | ALDH1A1 (0.39) | MEN1KMT2AATMALDH1A1HRH4 | |
| SCHEMBL3254185 | 0.85 | KDM1A (0.48) | MEN1KMT2AATMALDH1A1HTT | |
| SCHEMBL3253949 | 0.85 | KDM1A (0.48) | MEN1KMT2AATMALDH1A1HTT | |
| SCHEMBL3256393 | 0.83 | KDM1A (0.45) | MEN1KMT2AATMNPC1ALDH1A1 | |
| SCHEMBL3251081 | 0.83 | KDM1A (0.45) | MEN1KMT2AATMNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006528178-A | — | — | 2006-12-14 | — | — | JP | claimed |
| EP-1651613-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | Aventis Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | claimed |
| WO-2005014555-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-02-17 | — | — | WO | claimed |