Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2614863 | 0.90 | PRKCI (0.52) | PRKCIKDM4ECHRM4ABCB1ABCG2 | |
| Hydrochloric Acid SCHEMBL5729967 | 0.89 | PRKCI (0.51) | PRKCIKDM4ECHRM4ABCB1ABCG2 | |
| SCHEMBL1321209 | 0.88 | PRKCI (0.49) | PRKCIKDM4ECHRM4ABCB1ABCG2 | |
| SCHEMBL1322263 | 0.88 | PRKCI (0.50) | PRKCIKDM4ECHRM4ABCB1ABCG2 | |
| SCHEMBL1322016 | 0.88 | PRKCI (0.50) | PRKCIKDM4ECHRM4ABCB1ABCG2 | |
| SCHEMBL2614862 | 0.87 | PRKCI (0.54) | PRKCIKDM4ECHRM4PRKCZTSHR | |
| SCHEMBL5731616 | 0.86 | PRKCI (0.54) | PRKCIKDM4ECHRM4PRKCZTSHR | |
| SCHEMBL1322562 | 0.86 | PRKCI (0.50) | PRKCIKDM4ECHRM4PRKCZTSHR | |
| SCHEMBL1321710 | 0.85 | HPGD (0.42) | PRKCIKDM4EPRKCZLMNAMAPT | |
| SCHEMBL1321542 | 0.84 | PRKCI (0.52) | PRKCIKDM4ECHRM4PRKCZTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619196-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |