Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.70 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.70 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.70 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20878863 | 0.84 | ADORA2A (0.72) | ADORA2AADORA2BADORA1HSP90B1ADORA3 | |
| SCHEMBL1965296 | 0.82 | ADORA2A (1.00) | ADORA2AADORA2BADORA1HSP90B1ADORA3 | |
| SCHEMBL29157955 | 0.78 | ADORA2A (0.64) | ADORA2AADORA2BADORA1HSP90B1ADORA3 | |
| SCHEMBL5072517 | 0.77 | ADORA2A (0.85) | ADORA2AADORA2BADORA1HSP90B1ADORA3 | |
| SCHEMBL5732048 | 0.76 | ADORA2A (0.72) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL2980005 | 0.76 | ADORA2A (0.64) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL1966178 | 0.74 | HSP90AA1 (0.75) | HSP90B1HSP90AA1HSP90AB1ERBB2 | |
| SCHEMBL14044861 | 0.74 | HSP90AA1 (0.83) | ADORA2AADORA2BADORA1HSP90AA1HSP90AB1 | |
| SCHEMBL22359153 | 0.74 | ADORA2A (0.59) | ADORA2AADORA2BADORA1HSP90B1ADORA3 | |
| SCHEMBL30503500 | 0.74 | ADORA2A (0.59) | ADORA2AADORA2BADORA1HSP90B1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043021-B1 | PURINE DERIVATIVES FOR THE TREATMENT OF ALLERGIC DISEASES AND SYSTEMIC LUPUS ERYTHEMATOSUS | DAINIPPON SUMITOMO PHARMA CO (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-0882727-B9 | NOVEL PURINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-0882727-B1 | NOVEL PURINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-6376501-B1 | INHIBITING OR REGULATING IMMUNE RESPONSE USING PURINE-DERIVED COMPOUND; NON-STEROIDAL COMPOUND | JAPAN ENERGY CORPORATION (JP) | 2002-04-23 | — | — | US | disclosed |
| EP-1043021-A1 | TYPE 2 HELPER T CELL-SELECTIVE IMMUNE RESPONSE SUPPRESSORS | Japan Energy Corporation (JP) | 2000-10-11 | — | — | EP | disclosed |
| US-6028076-A | FOR INDUCING .ALPHA.-INTERFERON IN A PATIENT HAVING HEPATITIS B OR C, BY ADMINISTERING PURINE DERIVATIVE | JAPAN ENERGY CORPORATION (JP) | 2000-02-22 | — | — | US | disclosed |
| EP-0882727-A1 | NOVEL PURINE DERIVATIVES | JAPAN ENERGY CORPORATION (JP) | 1998-12-09 | — | — | EP | disclosed |