Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.41 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731997 | 1.00 | MEN1 (0.43) | MEN1KMT2ASMN1; SMN2DYRK1AFSCN1 | |
| SCHEMBL9048861 | 0.72 | SMN1; SMN2 (0.46) | MEN1KMT2ASMN1; SMN2DYRK1AFSCN1 | |
| SCHEMBL11163768 | 0.69 | KMT2A (0.49) | MEN1KMT2ASMN1; SMN2DYRK1AFSCN1 | |
| SCHEMBL5731637 | 0.69 | KMT2A (0.46) | MEN1KMT2ASMN1; SMN2DYRK1AFSCN1 | |
| SCHEMBL5731438 | 0.68 | DYRK1A (0.47) | MEN1KMT2ASMN1; SMN2DYRK1AFSCN1 | |
| SCHEMBL8124144 | 0.66 | MAPT (0.50) | MEN1KMT2ASMN1; SMN2DYRK1AFSCN1 | |
| SCHEMBL29956363 | 0.66 | DYRK1A (0.44) | DYRK1AFSCN1MAPTABL1ADORA1 | |
| SCHEMBL20422013 | 0.66 | MAPT (0.51) | MEN1KMT2ASMN1; SMN2DYRK1AFSCN1 | |
| SCHEMBL27459154 | 0.65 | ALDH1A1 (0.47) | MEN1KMT2ASMN1; SMN2DYRK1AFSCN1 | |
| SCHEMBL1233961 | 0.64 | PIK3CG (0.51) | MEN1KMT2ASMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060270656-A1 | Substituted piperazines of azepines, oxazepines and thiazepines | ELI LILLY AND COMPANY | 2006-11-30 | — | — | US | disclosed |
| EP-1664063-A1 | SUBSTITUTED PIPERAZINES OF AZEPINES, OXAZEPINES, AND THIAZEPINES | ELI LILLY AND COMPANY (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026177-A1 | SUBSTITUTED PIPERAZINES OF AZEPINES, OXAZEPINES, AND THIAZEPINES | ELI LILLY AND COMPANY (US) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270656-A1 | Substituted piperazines of azepines, oxazepines and thiazepines | HRH4, HRH2, HRH3 | MEN1 4241/4885KMT2A 3744/4885SMN1; SMN2 2565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.