Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.69 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.69 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.54 |
| ▸ | PI4KA | P42356 | 4/20 | 0.54 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.54 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.54 |
| ▸ | FBP1 | P09467 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | AHCY | P23526 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5732373 | 0.82 | ADORA2A (1.00) | ADORA2AADORA3ADORA1ADORA2BPI4KB | |
| SCHEMBL31061173 | 0.81 | ADORA2A (1.00) | ADORA2AADORA3ADORA1ADORA2BPI4KB | |
| SCHEMBL31061415 | 0.79 | ADORA2A (1.00) | ADORA2AADORA3ADORA1ADORA2BPI4KB | |
| SCHEMBL19714857 | 0.76 | ADCY5 (0.65) | ADORA2AADORA3ADORA1ADORA2BFBP1 | |
| SCHEMBL19714867 | 0.75 | ADCY5 (0.47) | ADORA2AADORA3ADORA1ADORA2BFBP1 | |
| SCHEMBL23422245 | 0.72 | ADORA2A (0.47) | ADORA2AADORA3ADORA1ADORA2BPI4KB | |
| SCHEMBL2980005 | 0.70 | ADORA2A (0.64) | ADORA2AADORA3ADORA1ADORA2BPI4KB | |
| SCHEMBL978424 | 0.70 | ADORA2A (1.00) | ADORA2AADORA3ADORA1ADORA2BPI4KB | |
| SCHEMBL6302264 | 0.69 | ADORA3 (0.66) | ADORA2AADORA3SMN1; SMN2HSPA5HSPA8 | |
| SCHEMBL13835070 | 0.69 | ADORA3 (0.66) | ADORA2AADORA3SMN1; SMN2HSPA5HSPA8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043021-B1 | PURINE DERIVATIVES FOR THE TREATMENT OF ALLERGIC DISEASES AND SYSTEMIC LUPUS ERYTHEMATOSUS | DAINIPPON SUMITOMO PHARMA CO (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-0882727-B9 | NOVEL PURINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-0882727-B1 | NOVEL PURINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-6376501-B1 | INHIBITING OR REGULATING IMMUNE RESPONSE USING PURINE-DERIVED COMPOUND; NON-STEROIDAL COMPOUND | JAPAN ENERGY CORPORATION (JP) | 2002-04-23 | — | — | US | disclosed |
| EP-1043021-A1 | TYPE 2 HELPER T CELL-SELECTIVE IMMUNE RESPONSE SUPPRESSORS | Japan Energy Corporation (JP) | 2000-10-11 | — | — | EP | disclosed |
| US-6028076-A | FOR INDUCING .ALPHA.-INTERFERON IN A PATIENT HAVING HEPATITIS B OR C, BY ADMINISTERING PURINE DERIVATIVE | JAPAN ENERGY CORPORATION (JP) | 2000-02-22 | — | — | US | disclosed |
| EP-0882727-A1 | NOVEL PURINE DERIVATIVES | JAPAN ENERGY CORPORATION (JP) | 1998-12-09 | — | — | EP | disclosed |