Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5377677 | 0.92 | GAA (0.50) | GAAHDAC6ACHEKCNH2HRH3 | |
| SCHEMBL5732388 | 0.83 | GAA (0.49) | GAAHDAC6ACHEF2TNKS | |
| SCHEMBL5374200 | 0.81 | GAA (0.45) | GAAHDAC6ACHEF2SIGMAR1 | |
| SCHEMBL5371447 | 0.81 | HDAC6 (0.55) | GAAHDAC6ACHEF2TNKS | |
| SCHEMBL5375990 | 0.79 | GAA (0.51) | GAAHDAC6ACHEF2TNKS | |
| SCHEMBL7220278 | 0.79 | GAA (0.45) | GAAHDAC6ACHEF2TNKS | |
| SCHEMBL5377672 | 0.77 | HDAC6 (0.49) | GAAHDAC6ACHEF2TNKS | |
| SCHEMBL5369583 | 0.77 | GAA (0.45) | GAAHDAC6ACHEF2TNKS | |
| SCHEMBL5374870 | 0.77 | GAA (0.51) | GAAHDAC6ACHEF2TNKS | |
| SCHEMBL7073760 | 0.76 | SIGMAR1 (0.47) | GAAHDAC6ACHEF2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |