Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.77 |
| ▸ | CTSK | P43235 | 13/20 | 0.77 |
| ▸ | CTSB | P07858 | 4/20 | 0.59 |
| ▸ | CTSL | P07711 | 2/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5732509 | 1.00 | CTSS (0.77) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL5564256 | 0.92 | CTSS (0.75) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL5564249 | 0.92 | CTSS (0.75) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL20814294 | 0.89 | CTSS (0.62) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL15989226 | 0.88 | CTSS (0.77) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL2793925 | 0.88 | CTSS (0.76) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL1001781 | 0.88 | CTSS (0.76) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL3758017 | 0.87 | CTSS (0.75) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL3763891 | 0.87 | CTSS (0.75) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL4374188 | 0.86 | CTSS (0.74) | CTSSCTSKCTSBCTSLSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664063-A1 | SUBSTITUTED PIPERAZINES OF AZEPINES, OXAZEPINES, AND THIAZEPINES | ELI LILLY AND COMPANY (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026177-A1 | SUBSTITUTED PIPERAZINES OF AZEPINES, OXAZEPINES, AND THIAZEPINES | ELI LILLY AND COMPANY (US) | 2005-03-24 | — | — | WO | disclosed |