Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273593 | 0.86 | NR1H4 (0.50) | KDM4EHSD17B10CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL272932 | 0.84 | NR1H4 (0.52) | KDM4EHSD17B10CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL687853 | 0.81 | CYP2D6 (0.52) | KDM4EHSD17B10CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL273946 | 0.78 | NR1H4 (0.49) | KDM4EHSD17B10CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL273340 | 0.73 | KDM4E (0.54) | KDM4EHSD17B10CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL273651 | 0.72 | NR1H4 (0.51) | KDM4EHSD17B10CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL278969 | 0.71 | NR1H4 (0.58) | KDM4EHSD17B10CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL688263 | 0.71 | KMT2A (0.38) | MAPK1MEN1KMT2A | |
| SCHEMBL273092 | 0.71 | KDM4E (0.62) | KDM4EHSD17B10CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL273595 | 0.71 | NR1H4 (0.52) | KDM4EHSD17B10CYP2D6CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692136-A2 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X-Ceptor Therapeutics, Inc. (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056554-A2 | AZEPINOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2005-06-23 | — | — | WO | disclosed |
| EP-1532153-A1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X-Ceptor Therapeutics, Inc. (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2003099821-A1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X-CEPTOR THERAPEUTICS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |