Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19866041 | 0.84 | NR1H4 (0.40) | KMT2AMEN1TUBB4ATUBBTUBA3C | |
| SCHEMBL273508 | 0.83 | NR1H4 (0.49) | — | |
| SCHEMBL5731809 | 0.77 | MAPKAPK2 (0.40) | KMT2AMEN1TUBB4ATUBBTUBA3C | |
| SCHEMBL4441689 | 0.73 | NR1H4 (0.49) | KMT2AMEN1TUBB4ATUBBTUBA3C | |
| SCHEMBL19866042 | 0.72 | TUBB4A (0.36) | KMT2AMEN1TUBB4ATUBBTUBA3C | |
| SCHEMBL5403859 | 0.71 | GPR17 (0.38) | KMT2AMEN1TUBB4ATUBBTUBA3C | |
| SCHEMBL5732632 | 0.71 | KDM4E (0.42) | KMT2AMEN1MAPK1 | |
| SCHEMBL1241340 | 0.70 | NR1H4 (0.37) | KMT2AMEN1TUBB4ATUBBTUBA3C | |
| SCHEMBL687853 | 0.69 | CYP2D6 (0.52) | KMT2AMEN1MAPKAPK2MAPK1 | |
| SCHEMBL273651 | 0.68 | NR1H4 (0.51) | KMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532153-B1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X CEPTOR THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |