Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3319710 | 1.00 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2P2RX7ALDH1A1 | |
| SCHEMBL20569205 | 0.91 | HDAC1 (0.45) | RAB9ANPC1SMN1; SMN2P2RX7ALDH1A1 | |
| SCHEMBL3323347 | 0.88 | SMN1; SMN2 (0.47) | RAB9ANPC1SMN1; SMN2P2RX7ALDH1A1 | |
| SCHEMBL5731482 | 0.88 | SMN1; SMN2 (0.47) | RAB9ANPC1SMN1; SMN2P2RX7ALDH1A1 | |
| SCHEMBL5731641 | 0.86 | HTT (0.52) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL3320689 | 0.86 | HTT (0.52) | RAB9ANPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL3318864 | 0.82 | SMN1; SMN2 (0.44) | RAB9ANPC1SMN1; SMN2P2RX7ALDH1A1 | |
| SCHEMBL5807714 | 0.82 | SMN1; SMN2 (0.44) | RAB9ANPC1SMN1; SMN2P2RX7ALDH1A1 | |
| SCHEMBL5732994 | 0.76 | RAB9A (0.39) | RAB9ANPC1SMN1; SMN2P2RX7ALDH1A1 | |
| SCHEMBL5731486 | 0.75 | RAB9A (0.36) | RAB9ANPC1SMN1; SMN2P2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709003-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | Wyeth (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073198-A1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE | WYETH (US) | 2005-08-11 | — | — | WO | disclosed |