Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.53 |
| ▸ | HRH1 | P35367 | 10/20 | 0.47 |
| ▸ | CCR3 | P51677 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4228844 | 0.80 | HRH3 (0.63) | HRH3HRH1CCR3KCNH2 | |
| Hydrochloric Acid SCHEMBL4234987 | 0.79 | HRH3 (0.62) | HRH3HRH1CCR3KCNH2 | |
| SCHEMBL4229745 | 0.74 | HRH3 (0.60) | HRH3HRH1CCR3KCNH2CYP2D6 | |
| Hydrochloric Acid SCHEMBL4228531 | 0.72 | HRH3 (0.72) | HRH3HRH1CCR3KCNH2 | |
| Hydrochloric Acid SCHEMBL4229879 | 0.72 | HRH3 (0.72) | HRH3HRH1CCR3KCNH2 | |
| SCHEMBL4233234 | 0.71 | HRH3 (0.63) | HRH3HRH1KCNH2CYP2D6 | |
| Hydrochloric Acid SCHEMBL4233282 | 0.71 | HRH3 (0.65) | HRH3HRH1KCNH2CYP2D6 | |
| SCHEMBL430313 | 0.70 | HRH3 (0.53) | HRH3KCNH2CYP2D6 | |
| SCHEMBL2822372 | 0.70 | HRH3 (0.61) | HRH3KCNH2 | |
| SCHEMBL4224609 | 0.70 | HRH3 (0.58) | HRH3HRH1CCR3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554243-B1 | BICYCLIC BENZAMIDE COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGAND USEFUL IN THE TREATMENT OF NEUROLOGICAL DISEASES | GLAXO GROUP LTD (GB) | 2006-11-22 | — | — | EP | claimed |