Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3305301 | 0.93 | HRH3 (0.56) | HRH3KCNH2 | |
| SCHEMBL737639 | 0.85 | HRH3 (0.63) | HRH3KCNH2 | |
| SCHEMBL14862124 | 0.84 | HRH3 (0.48) | HRH3KCNH2 | |
| SCHEMBL16712653 | 0.83 | HRH3 (0.61) | HRH3KCNH2 | |
| SCHEMBL256373 | 0.82 | PARP10 (0.53) | HRH3 | |
| SCHEMBL4464014 | 0.81 | HRH3 (0.68) | HRH3KCNH2 | |
| SCHEMBL2005027 | 0.81 | HRH3 (0.58) | HRH3KCNH2 | |
| SCHEMBL17533980 | 0.81 | HRH3 (0.58) | HRH3KCNH2 | |
| SCHEMBL2930586 | 0.80 | HRH3 (0.53) | HRH3KCNH2 | |
| SCHEMBL2930585 | 0.80 | HRH3 (0.53) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160095848-A1 | PHENYLPYRROLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2016-04-07 | — | — | US | disclosed |
| US-9284324-B2 | Phenylpyrrole derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2016-03-15 | — | — | US | disclosed |
| WO-2015069110-A1 | MULTIPLE D2 A(NTA)GONISTS/H3 ANTAGONISTS FOR TREATMENT OF CNS-RELATED DISORDERS | AAPA B.V. (NL) | 2015-05-14 | — | — | WO | disclosed |
| US-20150045553-A1 | PHENYLTRIAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2015-02-12 | — | — | US | disclosed |
| US-20140330010-A1 | PHENYLPYRROLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2014-11-06 | — | — | US | disclosed |
| EP-2799436-A1 | PHENYLTRIAZOLE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2014-11-05 | — | — | EP | disclosed |
| EP-2789608-A1 | PHENYLPYRROLE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2014-10-15 | — | — | EP | disclosed |
| EP-2007735-B1 | 2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2010-10-27 | — | — | EP | disclosed |
| US-20100113776-A1 | PYRAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO.,LTD. (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20090105225-A1 | 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | US | disclosed |
| EP-2007735-A1 | 2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS | Glaxo Group Limited (GB) | 2008-12-31 | — | — | EP | disclosed |
| US-20080039444-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-02-14 | — | — | US | disclosed |
| WO-2007122156-A9 | 2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2007122156-A1 | 2-SUBSTITUTED 4-BENZYLPHTHALAZINONE DERIVATIVES AS HISTAMINE H1 AND H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045553-A1 | PHENYLTRIAZOLE DERIVATIVE | PER2, BACE1, MAPT | HRH3 56/4885KCNH2 1119/4885 |
| US-20160095848-A1 | PHENYLPYRROLE DERIVATIVE | PER2, CRY1, APP | HRH3 40/4885KCNH2 1148/4885 |
| US-20140330010-A1 | PHENYLPYRROLE DERIVATIVE | PER2, CRY1, APP | HRH3 40/4885KCNH2 1148/4885 |
| US-20100113776-A1 | PYRAZOLE DERIVATIVE | HRH3, HRH4, HRH1 | HRH3 1/4885KCNH2 1314/4885 |
| US-20080039444-A1 | COMPOUNDS | CMA1, MRGPRX2, HRH2 | HRH3 16/4885KCNH2 1588/4885 |
| US-20090105225-A1 | 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists | HRH2, HRH3, HRH4 | HRH3 2/4885KCNH2 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.