Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5733276 | 1.00 | TAS1R3 (0.49) | TAS1R3TAS1R1PDE4APDE4BPDE4C | |
| SCHEMBL5734886 | 0.89 | PDE4B (0.54) | TAS1R3TAS1R1PDE4APDE4BPDE4C | |
| SCHEMBL5736521 | 0.86 | SMPD1 (0.59) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL5734935 | 0.85 | PDE4D (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5735485 | 0.84 | PDE4B (0.52) | TAS1R3TAS1R1PDE4APDE4BPDE4C | |
| SCHEMBL5735482 | 0.84 | PDE4B (0.52) | TAS1R3TAS1R1PDE4APDE4BPDE4C | |
| SCHEMBL5736544 | 0.84 | PDE4D (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5736549 | 0.84 | PDE4D (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7204083 | 0.84 | TAS1R3 (0.51) | TAS1R3TAS1R1PDE4APDE4BPDE4C | |
| SCHEMBL5737318 | 0.84 | TAS1R3 (0.51) | TAS1R3TAS1R1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1650193-A2 | 6-Phenylphenanthridines with PDE-IV inhibiting activity | ALTANA Pharma AG (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1147089-B1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| US-6476025-B1 | Phenylphennanthridines with PDE-IV inhibiting activity | ALTANA PHARMA AG (DE) | 2002-11-05 | — | — | US | disclosed |
| EP-1147089-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042020-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |