Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5736521 | 0.94 | SMPD1 (0.59) | PDE4APDE4BPDE4CPDE4DSMPD1 | |
| SCHEMBL5734886 | 0.91 | PDE4B (0.54) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL5735482 | 0.89 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5735485 | 0.89 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5734204 | 0.88 | PDE4B (0.53) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5734199 | 0.88 | PDE4B (0.53) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6167359 | 0.88 | PDE4B (0.53) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6167355 | 0.88 | PDE4B (0.53) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL5733984 | 0.84 | PDE4B (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5733988 | 0.84 | PDE4B (0.62) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1650193-A2 | 6-Phenylphenanthridines with PDE-IV inhibiting activity | ALTANA Pharma AG (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1147089-B1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| US-6476025-B1 | Phenylphennanthridines with PDE-IV inhibiting activity | ALTANA PHARMA AG (DE) | 2002-11-05 | — | — | US | disclosed |