Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.53 |
| ▸ | PDE4A | P27815 | 4/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5734199 | 1.00 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DTAS1R3 | |
| SCHEMBL5734204 | 1.00 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DTAS1R3 | |
| SCHEMBL6167355 | 1.00 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DTAS1R3 | |
| SCHEMBL5735482 | 0.99 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DTAS1R3 | |
| SCHEMBL5735485 | 0.99 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DTAS1R3 | |
| SCHEMBL5734886 | 0.94 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DTAS1R3 | |
| SCHEMBL5733652 | 0.88 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL5733988 | 0.87 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5733984 | 0.87 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5735938 | 0.85 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DTAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147089-B1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| US-6476025-B1 | Phenylphennanthridines with PDE-IV inhibiting activity | ALTANA PHARMA AG (DE) | 2002-11-05 | — | — | US | disclosed |
| EP-1147089-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042020-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |