Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5733938 | 0.84 | HDAC6 (0.42) | KCNH2GAAFAAHMGLLMEN1 | |
| SCHEMBL5734216 | 0.76 | GAA (0.44) | GAAMEN1KMT2AMAPTHTT | |
| SCHEMBL5374582 | 0.74 | GAA (0.47) | GAAMEN1KMT2AMAPTHTT | |
| SCHEMBL7076394 | 0.71 | KCNH2 (0.47) | KCNH2HRH3GAAMEN1KMT2A | |
| SCHEMBL1063457 | 0.71 | MGLL (0.61) | KCNH2HRH3GAAFAAHMGLL | |
| SCHEMBL5733936 | 0.70 | HDAC6 (0.52) | KCNH2HRH3FAAHMGLLPOLB | |
| SCHEMBL7443112 | 0.69 | MEN1 (0.52) | GAAMEN1KMT2AMAPTHTT | |
| SCHEMBL7617666 | 0.67 | MAPT (0.55) | GAAMEN1KMT2AMAPTHTT | |
| SCHEMBL5377677 | 0.67 | GAA (0.50) | KCNH2HRH3GAAMGLLHDAC6 | |
| SCHEMBL7238059 | 0.67 | MEN1 (0.53) | MEN1KMT2APOLBAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | disclosed |