Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.41 |
| ▸ | BRAF | P15056 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158683 | 0.85 | USP2 (0.42) | RAF1BRAFKDRTEKHDAC11 | |
| SCHEMBL4798990 | 0.84 | RAF1 (0.41) | RAF1BRAFKDRHDAC11CSNK1A1 | |
| SCHEMBL5733440 | 0.82 | KDR (0.56) | RAF1BRAFKDRTEKALDH1A1 | |
| SCHEMBL5733146 | 0.71 | KDR (0.58) | RAF1BRAFKDRTEKALDH1A1 | |
| SCHEMBL4172140 | 0.70 | KDR (0.43) | RAF1BRAFKDRTEKCSNK1A1 | |
| SCHEMBL4173612 | 0.69 | RAF1 (0.55) | RAF1BRAFKDRTEKALDH1A1 | |
| SCHEMBL4165936 | 0.69 | KDR (0.58) | RAF1BRAFKDRCSNK1A1CSNK1D | |
| SCHEMBL4161807 | 0.69 | KDR (0.52) | RAF1BRAFKDRTEKCSNK1A1 | |
| SCHEMBL4166878 | 0.68 | MGAM (0.49) | RAF1KDRTEKALDH1A1HPGD | |
| SCHEMBL4166869 | 0.67 | POLB (0.61) | RAF1BRAFKDRTEKCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675849-A1 | BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-07-05 | — | — | EP | claimed |
| WO-2005042520-A1 | BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-05-12 | — | — | WO | claimed |
| EP-1675849-A1 | BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005042520-A1 | BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-05-12 | — | — | WO | disclosed |