Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.56 |
| ▸ | RAF1 | P04049 | 10/20 | 0.56 |
| ▸ | BRAF | P15056 | 9/20 | 0.56 |
| ▸ | TEK | Q02763 | 3/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5733146 | 0.89 | KDR (0.58) | KDRRAF1BRAFTEKCSNK1A1 | |
| SCHEMBL4173612 | 0.85 | RAF1 (0.55) | KDRRAF1BRAFTEKCSNK1A1 | |
| SCHEMBL4166869 | 0.82 | POLB (0.61) | KDRRAF1BRAFTEKCSNK1A1 | |
| SCHEMBL5734205 | 0.82 | RAF1 (0.41) | KDRRAF1BRAFTEKCSNK1A1 | |
| SCHEMBL4158747 | 0.82 | KDR (0.59) | KDRRAF1BRAFCSNK1A1CSNK1D | |
| SCHEMBL13906245 | 0.79 | KDR (0.59) | KDRRAF1BRAFTEKCSNK1A1 | |
| SCHEMBL13906239 | 0.79 | KDR (0.54) | KDRRAF1BRAFTEKCSNK1A1 | |
| SCHEMBL4164763 | 0.78 | KDR (0.54) | KDRRAF1BRAFTEKCSNK1A1 | |
| SCHEMBL4161824 | 0.77 | CSNK1D (0.80) | KDRRAF1BRAFCSNK1A1CSNK1D | |
| SCHEMBL4164501 | 0.77 | RIPK1 (0.67) | KDRRAF1BRAFCSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675849-A1 | BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-07-05 | — | — | EP | claimed |
| WO-2005042520-A1 | BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-05-12 | — | — | WO | claimed |
| EP-1675849-A1 | BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005042520-A1 | BENZIMIDAZOLYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-05-12 | — | — | WO | disclosed |