⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487164 | 0.93 | — | — | |
| SCHEMBL8485192 | 0.92 | — | — | |
| SCHEMBL8490827 | 0.90 | NAMPT (0.51) | — | |
| SCHEMBL9299503 | 0.89 | NAMPT (0.44) | — | |
| SCHEMBL9389148 | 0.86 | — | — | |
| SCHEMBL8488936 | 0.86 | NAMPT (0.38) | — | |
| SCHEMBL9249466 | 0.86 | NAMPT (0.47) | — | |
| SCHEMBL9389156 | 0.86 | — | — | |
| SCHEMBL9389115 | 0.85 | NAMPT (0.36) | — | |
| SCHEMBL8489850 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060189804-A1 | Synthetic method for the preparation of quinazolin-4-one derivative | BTG INTERNATIONAL LIMITED (GB) | 2006-08-24 | — | — | US | disclosed |
| EP-1675831-A2 | SYNTHETIC METHOD FOR THE PREPARATION OF QUINAZOLIN-4-ONE DERIVATIVES | BTG INTERNATIONAL LIMITED (GB) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005012260-A2 | SYNTHETIC METHOD FOR THE PREPARATION OF QUINAZOLIN-4-ONE DERIVATIVE | BTG INTERNATIONAL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
| US-5955463-A | ANTITUMOR, ANTIINFLAMMATORY, AND ANTIARTHRITIC AGENTS | ZENECA LIMITED (GB) | 1999-09-21 | — | — | US | disclosed |
| US-5280027-A | Quinazoline containing compound | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-18 | — | — | US | disclosed |