Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 15/20 | 0.40 |
| ▸ | HTR2B | P41595 | 14/20 | 0.40 |
| ▸ | HTR2A | P28223 | 9/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | C1S | P09871 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5631600 | 1.00 | HTR2C (0.40) | HTR2CHTR2BHTR2AADRB1C1S | |
| SCHEMBL5632697 | 0.88 | ADRB1 (0.49) | HTR2CHTR2BHTR2AADRB1 | |
| SCHEMBL5630914 | 0.88 | ADRB1 (0.49) | HTR2CHTR2BHTR2AADRB1 | |
| SCHEMBL5630920 | 0.88 | ADRB1 (0.49) | HTR2CHTR2BHTR2AADRB1 | |
| Trifluoroacetic Acid SCHEMBL5632354 | 0.86 | KDM1A (0.36) | HTR2CHTR2BHTR2A | |
| Trifluoroacetic Acid SCHEMBL5632499 | 0.86 | KDM1A (0.36) | HTR2CHTR2BHTR2A | |
| Trifluoroacetic Acid SCHEMBL5631588 | 0.83 | HTR2C (0.41) | HTR2CHTR2BHTR2A | |
| Trifluoroacetic Acid SCHEMBL5632974 | 0.78 | HTR2C (0.38) | HTR2CHTR2BHTR2ATACR1 | |
| SCHEMBL4430749 | 0.77 | HTR2C (0.49) | HTR2CHTR2BHTR2A | |
| Trifluoroacetic Acid SCHEMBL5631649 | 0.76 | HTR2C (0.41) | HTR2CHTR2BHTR2AC1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809545-A | N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5HT2c | ARENA PHARM INC (US) | 2006-07-26 | — | — | CN | disclosed |
| EP-1644347-A1 | N-PHENYL-PIPERAZINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT sb 2C /sb RECEPTOR ASSOCIATED DISEASES | Arena Pharmaceuticals, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005016902-A1 | N-PHENYL-PIPERAZINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT2C RECEPTOR ASSOCIATED DISEASES | ARENA PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |