Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.53 |
| ▸ | DPP4 | P27487 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5734608 | 1.00 | TTR (0.53) | TTRDPP4NPC1CASP3RAB9A | |
| SCHEMBL6785077 | 0.92 | NPC1 (0.51) | TTRDPP4NPC1CASP3RAB9A | |
| SCHEMBL6785074 | 0.92 | NPC1 (0.51) | TTRDPP4NPC1CASP3RAB9A | |
| SCHEMBL5736775 | 0.76 | GAA (0.48) | NPC1RAB9AP2RY12APP | |
| SCHEMBL26791145 | 0.73 | TTR (0.59) | TTRDPP4NPC1CASP3RAB9A | |
| SCHEMBL30634275 | 0.73 | TTR (0.59) | TTRDPP4NPC1CASP3RAB9A | |
| SCHEMBL11217092 | 0.73 | TTR (0.71) | TTRDPP4NPC1CASP3RAB9A | |
| SCHEMBL11217091 | 0.73 | TTR (0.71) | TTRDPP4NPC1CASP3RAB9A | |
| SCHEMBL31634059 | 0.72 | TTR (0.58) | TTRDPP4NPC1CASP3RAB9A | |
| SCHEMBL13984057 | 0.72 | TTR (0.58) | TTRDPP4NPC1CASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686128-A2 | Isothiazole derivatives and their use as pesticides | Syngenta Limited (GB) | 2006-08-02 | — | — | EP | disclosed |
| EP-1265892-B1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LTD (GB) | 2006-01-18 | — | — | EP | disclosed |
| US-6703347-B2 | INSECTICIDES, FUNGICIDES, NEMATOCIDES, MOLLUSCICIDES, AND MITICIDES FOR PLANTS | SYNGENTA LIMITED (GB) | 2004-03-09 | — | — | US | disclosed |
| US-20030207926-A1 | Isothiazole derivatives and their use as pesticides | SYNGENTA LIMITED (GB) | 2003-11-06 | — | — | US | disclosed |
| EP-1265892-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | Syngenta Limited (GB) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001055144-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LIMITED (GB) | 2001-08-02 | — | — | WO | disclosed |
| WO-2001055139-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LIMITED (GB) | 2001-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207926-A1 | Isothiazole derivatives and their use as pesticides | CBR1, CBR3, CYP1B1 | TTR 1181/4885DPP4 2637/4885NPC1 2117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.