Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
| ▸ | STK3 | Q13188 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.52 |
| ▸ | BLK | P51451 | 1/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3580523 | 0.98 | ROCK2 (0.59) | ROCK2ROCK1CSNK2A1CLK4CLK2 | |
| Trifluoroacetic Acid SCHEMBL3581419 | 0.97 | ROCK2 (0.61) | ROCK2ROCK1CSNK2A1CLK4CLK2 | |
| Trifluoroacetic Acid SCHEMBL3586117 | 0.90 | ROCK2 (0.57) | ROCK2ROCK1CSNK2A1CLK4CLK2 | |
| Trifluoroacetic Acid SCHEMBL3582624 | 0.89 | ROCK2 (0.64) | ROCK2ROCK1CSNK2A1CLK4CLK2 | |
| Trifluoroacetic Acid SCHEMBL3582542 | 0.89 | ROCK2 (0.57) | ROCK2ROCK1CSNK2A1CLK4CLK2 | |
| Trifluoroacetic Acid SCHEMBL3579905 | 0.88 | ROCK2 (0.58) | ROCK2ROCK1CSNK2A1CLK4CLK2 | |
| Trifluoroacetic Acid SCHEMBL3581668 | 0.88 | ROCK2 (0.55) | ROCK2ROCK1CSNK2A1CLK4CLK2 | |
| Trifluoroacetic Acid SCHEMBL3588103 | 0.87 | ROCK2 (0.52) | ROCK2ROCK1CSNK2A1CLK4CLK2 | |
| Trifluoroacetic Acid SCHEMBL3580643 | 0.85 | ROCK2 (0.62) | ROCK2ROCK1CSNK2A1CLK4CLK2 | |
| Trifluoroacetic Acid SCHEMBL3588581 | 0.85 | ROCK2 (0.50) | ROCK2ROCK1CSNK2A1CLK4CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370553-B1 | RHO-KINASE INHIBITORS | BAYER AG (US) | 2006-05-10 | — | — | EP | claimed |