Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutaral SCHEMBL5733024 | 1.00 | LMNA (0.52) | LMNAMAPTHIF1ATSHRTRPV1 | |
| Glutaral SCHEMBL7174412 | 0.96 | LMNA (0.57) | LMNAMAPTHIF1ATSHRTRPV1 | |
| Glutaral SCHEMBL5733399 | 0.92 | LMNA (0.48) | LMNAMAPTHIF1ATSHRTRPV1 | |
| Glutaral SCHEMBL7886922 | 0.91 | LMNA (0.52) | LMNAMAPTHIF1ATSHRTRPV1 | |
| Glutaral SCHEMBL6229345 | 0.91 | LMNA (0.52) | LMNAMAPTHIF1ATSHRTRPV1 | |
| Pentanal SCHEMBL9295530 | 0.87 | TSHR (0.61) | LMNAMAPTHIF1ATSHRTRPV1 | |
| SCHEMBL11485155 | 0.86 | LMNA (0.63) | LMNAMAPTHIF1ATSHRTRPV1 | |
| Hexanal SCHEMBL10352184 | 0.85 | TSHR (0.60) | LMNAMAPTHIF1ATSHRTRPV1 | |
| Decanal SCHEMBL6949312 | 0.83 | TSHR (0.64) | LMNATSHRTRPV1FAAHALDH1A1 | |
| Heptanal SCHEMBL1664616 | 0.83 | TSHR (0.64) | LMNATSHRTRPV1FAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244646-B1 | DINITRILE INTERMEDIATES FOR THE SYNTHESIS OF OMAPATRILAT AND METHODS FOR PRODUCING SAME | DIXIE CHEMICAL CO (US) | 2006-08-23 | — | — | EP | disclosed |
| US-6300503-B1 | Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same | DIXIE CHEMICAL COMPANY | 2001-10-09 | — | — | US | disclosed |
| US-6284901-B1 | Dinitrile intermediates for the synthesis of omapatrilat and methods for producing same | DIXIE CHEMICAL COMPANY | 2001-09-04 | — | — | US | disclosed |
| WO-2001044202-A1 | HYDANTOIN INTERMEDIATES FOR THE SYNTHESIS OF OMAPATRILAT AND METHODS FOR PRODUCING AND USING THE SAME | DIXIE CHEMICAL COMPANY (US) | 2001-06-21 | — | — | WO | disclosed |