Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036133 | 0.84 | MEN1 (0.60) | MEN1CYP2D6KMT2AHDAC6SLC6A2 | |
| Hydrochloric Acid SCHEMBL20838548 | 0.83 | MEN1 (0.63) | MEN1CYP2D6KMT2AHDAC6SLC6A2 | |
| SCHEMBL20883790 | 0.79 | MEN1 (0.66) | MEN1CYP2D6KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6622933 | 0.77 | MEN1 (0.62) | MEN1CYP2D6KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4038817 | 0.76 | MEN1 (0.66) | MEN1CYP2D6KMT2ASLC6A2SLC6A4 | |
| SCHEMBL5733737 | 0.75 | HRH3 (0.54) | MEN1KMT2AHDAC1HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL27829790 | 0.75 | MEN1 (0.64) | MEN1CYP2D6KMT2AHDAC6ALDH1A1 | |
| SCHEMBL5735422 | 0.74 | MGLL (0.44) | MEN1KMT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL1582773 | 0.74 | KMT2A (0.96) | MEN1CYP2D6KMT2AALDH1A1KHK | |
| SCHEMBL28750644 | 0.74 | MEN1 (0.58) | MEN1CYP2D6KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986551-B1 | SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA PHARMACEUTICAL (JP) | 2006-08-02 | — | — | EP | disclosed |
| US-6359134-B1 | ANTICOAGULANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| EP-0986551-A1 | SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Pharmaceutical Company Limited (JP) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054164-A1 | SULFONAMIDE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-03 | — | — | WO | disclosed |