Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 13/20 | 0.52 |
| ▸ | FNTB | P49356 | 13/20 | 0.52 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174338 | 0.92 | FNTA (0.44) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL5737090 | 0.90 | FNTA (0.59) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL5071351 | 0.88 | FNTA (0.64) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL5734468 | 0.86 | CYP3A4 (0.53) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL1683530 | 0.86 | CYP3A4 (0.67) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL6172596 | 0.84 | FNTA (0.49) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL6173339 | 0.82 | FNTA (0.55) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL6171352 | 0.82 | FNTA (0.45) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL6172263 | 0.81 | FNTA (0.54) | FNTAFNTBPGGT1BCYP3A4 | |
| SCHEMBL6170815 | 0.79 | CYP3A4 (0.48) | FNTAFNTBPGGT1BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162201-B1 | Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2006-03-29 | — | — | EP | claimed |
| EP-1094815-B1 | FARNESYL PROTEIN TRANSFERASE INHIBITORS FOR TREATING ARTHROPATHIES | JANSSEN PHARMACEUTICA NV (BE) | 2003-11-12 | — | — | EP | claimed |
| EP-1094839-B1 | FARNESYL PROTEIN TRANSFERASE INHIBITORS WITH (IN VIVO) RADIOSENSITIZING PROPERTIES | JANSSEN PHARMACEUTICA NV (BE) | 2003-05-02 | — | — | EP | claimed |
| EP-0865440-B1 | FARNESYL PROTEIN TRANSFERASE INHIBITING (IMIDAZOL-5-YL)METHYL-2-QUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-04-03 | — | — | EP | claimed |