Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 19/20 | 0.68 |
| ▸ | PDK2 | Q15119 | 19/20 | 0.68 |
| ▸ | PDK3 | Q15120 | 19/20 | 0.68 |
| ▸ | PDK4 | Q16654 | 19/20 | 0.68 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5735169 | 1.00 | PDK1 (0.68) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5736842 | 0.89 | PDK1 (0.72) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5736844 | 0.89 | PDK1 (0.72) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5734909 | 0.86 | PDK1 (0.74) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5734671 | 0.86 | PDK1 (0.68) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5737812 | 0.84 | PDK1 (0.61) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5737401 | 0.84 | PDK1 (0.77) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL5738034 | 0.83 | PDK1 (0.70) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5738033 | 0.83 | PDK1 (0.70) | PDK1PDK2PDK3PDK4PTGES2 | |
| SCHEMBL5738674 | 0.82 | PDK1 (0.82) | PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064274-B1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |