Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3523295 | 1.00 | EGFR (0.62) | EGFRERBB2KDR | |
| SCHEMBL3521722 | 1.00 | EGFR (0.62) | EGFRERBB2KDR | |
| SCHEMBL3522078 | 0.95 | EGFR (0.61) | EGFRERBB2 | |
| SCHEMBL1675982 | 0.95 | EGFR (0.61) | EGFRERBB2 | |
| SCHEMBL3522106 | 0.93 | EGFR (0.60) | EGFRERBB2KDR | |
| SCHEMBL3524064 | 0.93 | EGFR (0.60) | EGFRERBB2KDR | |
| SCHEMBL13499950 | 0.92 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL3520041 | 0.91 | EGFR (0.57) | EGFRERBB2 | |
| SCHEMBL4735610 | 0.90 | EGFR (0.65) | EGFRERBB2 | |
| SCHEMBL3525133 | 0.90 | EGFR (0.65) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622620-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096226-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2004-11-11 | — | — | WO | disclosed |