Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 6/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573369 | 0.99 | KDR (0.49) | KDRRIPK1TEKBRAFNTRK1 | |
| SCHEMBL574207 | 0.94 | KDR (0.45) | KDRRIPK1TEKBRAFNTRK1 | |
| SCHEMBL573612 | 0.94 | KDR (0.51) | KDRRIPK1TEKBRAFNTRK1 | |
| SCHEMBL572653 | 0.91 | CNR1 (0.45) | KDRRIPK1 | |
| SCHEMBL573446 | 0.91 | RIPK1 (0.42) | KDRRIPK1TEKBRAFNTRK1 | |
| SCHEMBL574209 | 0.90 | CNR1 (0.44) | KDRRIPK1 | |
| SCHEMBL574212 | 0.90 | CNR1 (0.44) | KDRRIPK1 | |
| SCHEMBL574017 | 0.90 | NTRK1 (0.43) | KDRRIPK1NTRK1 | |
| SCHEMBL827574 | 0.89 | NTRK1 (0.48) | KDRRIPK1TEKBRAFNTRK1 | |
| SCHEMBL574134 | 0.89 | CNR1 (0.43) | KDRRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019015-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-02-09 | — | — | WO | disclosed |
| US-20110189167-A1 | Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases | DECIPHERA PHARMACEUTICALS, LLC | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110189167-A1 | Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases | MCL1, NRAS, ABL1 | KDR 2434/4885RIPK1 1293/4885TEK 3102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.