Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 4/20 | 0.46 |
| ▸ | CCNH | P51946 | 4/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | CCNK | O75909 | 2/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.46 |
| ▸ | JUN | P05412 | 3/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL518242 | 0.88 | EGFR (0.60) | EGFRALKJAK2JAK1CDK7 | |
| SCHEMBL517613 | 0.86 | EGFR (0.75) | EGFRALKJAK2JAK1CDK2 | |
| SCHEMBL573658 | 0.82 | EGFR (0.61) | EGFRALKJAK2JAK1CDK7 | |
| SCHEMBL517586 | 0.81 | ALK (0.65) | EGFRALKCDK7CCNHMNAT1 | |
| SCHEMBL518824 | 0.78 | ALK (0.67) | EGFRALKJAK2JAK1CDK7 | |
| SCHEMBL518394 | 0.78 | ALK (0.83) | EGFRALK | |
| SCHEMBL517036 | 0.78 | EGFR (0.74) | EGFRALKCDK2 | |
| SCHEMBL30956842 | 0.77 | ALK (0.57) | EGFRALKJAK2JAK1CDK7 | |
| SCHEMBL29232072 | 0.77 | ALK (0.57) | EGFRALKJAK2JAK1CDK7 | |
| SCHEMBL517301 | 0.76 | EGFR (0.72) | EGFRALKCDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601186-A2 | 4-(1H-INDOL-3-YL)-PYRIMIDINES AS ALK INHIBITORS | AstraZeneca AB (SE) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012017239-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2012-02-09 | — | — | WO | disclosed |