Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 5/20 | 0.56 |
| ▸ | PRKACG | P22612 | 4/20 | 0.56 |
| ▸ | PRKACB | P22694 | 4/20 | 0.56 |
| ▸ | AKT2 | P31751 | 3/20 | 0.56 |
| ▸ | PRKCG | P05129 | 5/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.54 |
| ▸ | PRKCB | P05771 | 4/20 | 0.54 |
| ▸ | PRKCA | P17252 | 4/20 | 0.54 |
| ▸ | PRKCH | P24723 | 4/20 | 0.54 |
| ▸ | PRKCI | P41743 | 4/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.54 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14094544 | 0.97 | PRKACA (0.60) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL29380289 | 0.77 | FLT3 (0.77) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL14094545 | 0.75 | PRKACA (0.59) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL5737710 | 0.74 | PRKACA (0.57) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL9541290 | 0.73 | PRKCG (0.86) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL14094554 | 0.73 | PRKACA (0.63) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL14094518 | 0.73 | PRKACA (0.68) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| Oxalic Acid SCHEMBL5009453 | 0.73 | MEN1 (0.46) | CYP3A4LMNAMEN1KMT2AHIF1A | |
| SCHEMBL29644982 | 0.72 | PRKACA (1.00) | PRKACAPRKACGPRKACBAKT2PRKCG | |
| SCHEMBL14094570 | 0.72 | PRKACA (0.47) | PRKACAPRKACGPRKACBAKT2PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611105-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004094386-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |