Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.74 |
| ▸ | PDK1 | Q15118 | 18/20 | 0.67 |
| ▸ | PDK2 | Q15119 | 18/20 | 0.67 |
| ▸ | PDK3 | Q15120 | 18/20 | 0.67 |
| ▸ | PDK4 | Q16654 | 18/20 | 0.67 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.63 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.63 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.63 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737843 | 1.00 | PTGES2 (0.74) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5748221 | 0.93 | PTGES2 (0.70) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5737838 | 0.91 | PDK1 (0.69) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5737922 | 0.90 | PDK1 (0.68) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5735953 | 0.90 | PDK1 (0.79) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5737845 | 0.90 | PDK1 (0.70) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5737589 | 0.90 | PDK1 (0.68) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5738172 | 0.90 | PDK1 (0.79) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5739202 | 0.90 | PTGES2 (0.66) | PTGES2PDK1PDK2PDK3PDK4 | |
| SCHEMBL5737580 | 0.89 | PDK1 (0.67) | PTGES2PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064274-B1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-6667342-B1 | Elevation of pyruvate dehydrogenase activity | ASTRAZENECA AB (SE) | 2003-12-23 | — | — | US | disclosed |
| EP-1064274-A1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999047508-A1 | BENZENESULFONAMIDE-DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 1999-09-23 | — | — | WO | disclosed |