Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | CLK2 | P49760 | 2/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737744 | 0.92 | PIK3CA (0.37) | PIK3CGPIK3CAPIK3CDPIK3CBCLK2 | |
| SCHEMBL1886584 | 0.85 | NOS2 (0.41) | PIK3CGPIK3CAPIK3CDPIK3CBCLK2 | |
| SCHEMBL1888493 | 0.84 | PIK3CG (0.38) | PIK3CGPIK3CAPIK3CDPIK3CBCLK2 | |
| SCHEMBL1882772 | 0.84 | PIK3CG (0.34) | PIK3CGPIK3CAPIK3CDPIK3CBCLK2 | |
| SCHEMBL1884087 | 0.83 | PIK3CA (0.39) | PIK3CGPIK3CAPIK3CDPIK3CBCLK2 | |
| SCHEMBL1888302 | 0.82 | PIK3CA (0.35) | PIK3CGPIK3CAPIK3CDPIK3CBCLK2 | |
| SCHEMBL1887699 | 0.82 | PIK3CG (0.34) | PIK3CGPIK3CAPIK3CDPIK3CBCLK2 | |
| SCHEMBL1883449 | 0.81 | PIK3CG (0.34) | PIK3CGPIK3CAPIK3CDPIK3CBCLK2 | |
| SCHEMBL1890711 | 0.81 | PIK3CG (0.40) | PIK3CGPIK3CAPIK3CDPIK3CBCLK2 | |
| SCHEMBL1884661 | 0.80 | PIK3CG (0.41) | PIK3CGPIK3CAPIK3CDDYRK1ACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622897-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | Novartis AG (CH) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096797-A1 | INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | NOVARTIS AG (CH) | 2004-11-11 | — | — | WO | disclosed |