Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978528 | 0.82 | NR1H4 (0.64) | TBXAS1NR1H4CYP3A4CYP2C9MEN1 | |
| SCHEMBL5737694 | 0.82 | NR1H4 (0.51) | FFAR1NR1H4CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL5737702 | 0.82 | NR1H4 (0.51) | FFAR1NR1H4CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6816293 | 0.77 | FFAR4 (0.56) | TBXAS1FFAR1NR1H4LTB4RLTB4R2 | |
| SCHEMBL27664774 | 0.77 | MEN1 (0.45) | FFAR1NR1H4CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL3550677 | 0.76 | KDM4E (0.60) | NR1H4LTB4RLTB4R2MEN1KMT2A | |
| SCHEMBL3550674 | 0.76 | KDM4E (0.60) | NR1H4LTB4RLTB4R2MEN1KMT2A | |
| SCHEMBL3095033 | 0.76 | GSK3B (0.51) | FFAR1ACACBACACAPKMKDM4E | |
| SCHEMBL3095019 | 0.76 | GSK3B (0.51) | FFAR1ACACBACACAPKMKDM4E | |
| SCHEMBL2301703 | 0.75 | LTB4R (0.48) | TBXAS1NR1H4LTB4RLTB4R2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615899-A1 | ALPHA-SUBSTITUTED CARBOXYLIC ACIDS AS PPAR MODULATORS | PFIZER INC. (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20050234066-A1 | Alpha substituted carboxylic acids | AGOURON PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050187266-A1 | Alpha substituted carboxylic acids | PFIZER INC | 2005-08-25 | — | — | US | disclosed |
| WO-2004092145-A1 | ALPHA SUBSTITUTED CARBOXYLIC ACID AS PPAR MODULATORS | PFIZER INC. (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234066-A1 | Alpha substituted carboxylic acids | PPARG, PPARA, PPARD | TBXAS1 653/4885FFAR1 5/4885NR1H4 70/4885 |
| US-20050187266-A1 | Alpha substituted carboxylic acids | PPARG, PPARA, PPARD | TBXAS1 653/4885FFAR1 5/4885NR1H4 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.