SCHEMBL5737896

SCHEMBL5737896

Cn1c2ccc(NS(C)(=O)=O)cc2c2c(C(=O)NOCc3c(Cl)cncc3Cl)cccc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 2/20 0.40
GRK2 P25098 1/20 0.37
ROCK1 Q13464 1/20 0.36
DHX9 Q08211 1/20 0.36
CYP17A1 P05093 2/20 0.35
AURKB Q96GD4 1/20 0.35
USP7 Q93009 1/20 0.35
USP47 Q96K76 1/20 0.35
ATM Q13315 1/20 0.34
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
ALDH1A1 P00352 2/20 0.33
F10 P00742 1/20 0.33
PPARG P37231 2/20 0.33
CYP3A4 P08684 1/20 0.33
HPGD P15428 2/20 0.33
KMT2A Q03164 1/20 0.33
NPC1 O15118 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5738861 0.92 CYP11B2 (0.37) PDE4DCYP17A1ALDH1A1PPARGCYP3A4
SCHEMBL5738928 0.88 NPC1 (0.39) GRK2ALDH1A1NPC1
SCHEMBL5739357 0.86 NPC1 (0.33) PDE4DPDE4APDE4BPDE4CKMT2A
SCHEMBL6532850 0.85 MEN1 (0.39) ALDH1A1KMT2ANPC1
SCHEMBL4032068 0.70 PDE4D (0.57) PDE4DPDE4APDE4BPDE4C
SCHEMBL6470780 0.68 PDE4B (0.42) PDE4DPDE4APDE4BPDE4C
SCHEMBL6533419 0.67 BTK (0.38) KMT2ANPC1
SCHEMBL5025239 0.67 NPC1 (0.42) PDE4DAURKBALDH1A1HPGDNPC1
SCHEMBL31461599 0.66 PDE4D (0.67) PDE4DGRK2USP7USP47PDE4A
SCHEMBL5025403 0.66 NPC1 (0.34) PDE4DGRK2PDE4BNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1620429-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Glenmark Pharmaceuticals S.A. (CH) 2006-02-01 EP claimed
WO-2004089940-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS S.A. (US) 2004-10-21 WO claimed
EP-1620429-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Glenmark Pharmaceuticals S.A. (CH) 2006-02-01 EP disclosed
WO-2004089940-A1 NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS S.A. (US) 2004-10-21 WO disclosed